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BDBM195387 US9670212, 51 3-amino-N-{[8-methyl-2-(methyl{2-[(1H-1,2,3-triazol-1-ylacetyl)amino]ethyl}amino)quinolin-3-yl]methyl}pyrazine-2-carboxamide

SMILES: CN(CCNC(=O)Cn1ccnn1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N

InChI Key: InChIKey=NRKRPAJOGPWEEV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 195387   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM195387
PNG
(US9670212, 51 3-amino-N-{[8-methyl-2-(methyl{2-[(1...)
Show SMILES CN(CCNC(=O)Cn1ccnn1)c1nc2c(C)cccc2cc1CNC(=O)c1nccnc1N
Show InChI InChI=1S/C23H26N10O2/c1-15-4-3-5-16-12-17(13-28-23(35)20-21(24)27-7-6-26-20)22(30-19(15)16)32(2)10-8-25-18(34)14-33-11-9-29-31-33/h3-7,9,11-12H,8,10,13-14H2,1-2H3,(H2,24,27)(H,25,34)(H,28,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/an/an/a



Exelixis Inc

US Patent


Assay Description
Kinase activity is measured as the percent of ATP consumed following the kinase reaction using luciferase-luciferin-coupled chemiluminescence. Reacti...


US Patent US9670212 (2017)


BindingDB Entry DOI: 10.7270/Q27H1GR0
More data for this
Ligand-Target Pair