BDBM195860 US9670213, Compound 005 8-(3-aminophenyl)-2-(4-methoxyphenyl)-7(8H)-pteridin-one

SMILES COc1ccc(Nc2ncc3ncc(=O)n(-c4cccc(N)c4)c3n2)cc1

InChI Key InChIKey=QKANEQHLFOWQRR-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 195860   

TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
East China University Of Science And Technology

US Patent
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

US Patent
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
East China University Of Science And Technology

US Patent
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50:  8.72E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
East China University Of Science And Technology

US Patent
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University Of Science And Technology

US Patent
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50:  30nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50:  5.59E+4nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50:  2.13E+4nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University Of Science And Technology

US Patent
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 (564 to 993 residues) expressed in baculovirus expression system using peptide FAM-P2 as substrate inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
East China University Of Science And Technology

US Patent
LigandPNGBDBM195860(US9670213, Compound 005 8-(3-aminophenyl)-2-(4-met...)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent