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BDBM198132 Ethyl 4-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-2-oxo-6-(pyridin-3-yl)cyclohex-3-enecarboxylate (5c)

SMILES: CCOC(=O)C1C(CC(=CC1=O)c1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1)c1cccnc1

InChI Key: InChIKey=JQQZTKBOWSGKLE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 198132   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Topoisomerase II alpha (HuTopoIIα)


(Homo sapiens (Human))
BDBM198132
PNG
(Ethyl 4-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-...)
Show SMILES CCOC(=O)C1C(CC(=CC1=O)c1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1)c1cccnc1
Show InChI InChI=1S/C29H24ClN3O3/c1-2-36-29(35)27-24(20-7-6-14-31-17-20)15-21(16-26(27)34)25-18-33(23-8-4-3-5-9-23)32-28(25)19-10-12-22(30)13-11-19/h3-14,16-18,24,27H,2,15H2,1H3
PDB

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UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a<1.00E+5n/an/an/an/a7.9n/a



Jamia Millia Islamia (A Central University)



Assay Description
Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 ÁL of reaction buffer (10 mM Tris-HCl, pH 7.9, 150...


Bioorg Chem 69: 77-90 (2016)


Article DOI: 10.1016/j.bioorg.2016.10.001
BindingDB Entry DOI: 10.7270/Q21V5CS9
More data for this
Ligand-Target Pair