BDBM19854 CHEMBL426819::CRA-013783/L-006235::N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide::basic piperazine-containing compound, 1

SMILES: CN1CCN(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N

InChI Key: InChIKey=FIVYCSWOCXEWSE-UHFFFAOYSA-N

Data: 2 KI  10 IC50  5 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 19854   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin K (Rabbit)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.25	n/a	n/a	n/a	n/a	5.5	22
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Procathepsin L (Human)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.30E+3	n/a	340	n/a	n/a	5.5	22
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Cathepsin B (Human)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	17	n/a	n/a	6.0	22
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Cathepsin S (Human)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.70E+4	n/a	790	n/a	n/a	6.5	22
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Cathepsin K (Rabbit)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	5	n/a	n/a	5.5	22
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Cathepsin S (Mouse)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40E+3	n/a	318	n/a	n/a	n/a	n/a
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Cathepsin S (Human)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin K (Human)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin B (Human)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Procathepsin L (Human)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin K (Rabbit)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin K (Rabbit)	BDBM19854 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...) Show SMILES Show InChI	GoogleScholar	UniChem		0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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