BindingDB PrimarySearch

BDBM19993 CHEMBL62136::N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide::T 0901317::T0901317::TO-901317::[3H]T0901317

InChI string: InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2

SMILES: OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=SGIWFELWJPNFDH-UHFFFAOYSA-N

Data: 2 KI 48 IC50 2 Kd 77 EC50

PDB links: 7 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 124 hits for monomerid = 19993
Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
RAR-related orphan receptor C (RORc) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Binding affinity to RORc (unknown origin) by radioligand binding assay				J Med Chem 57: 5871-92 (2014)
Genentech Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Nuclear receptor ROR-alpha (Homo sapiens)	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	Article PubMed	132	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Binding affinity to RORa (unknown origin) by radioligand binding assay				J Med Chem 57: 5871-92 (2014)
Genentech Curated by ChEMBL					More data for this Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	103	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta-LBD assessed as recruitment of co-activator peptide after 2 hrs by TR-FRET assay				Bioorg Med Chem Lett 23: 4185-90 (2013)
Korea University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Agonist activity at human LXRalpha-LBD assessed as recruitment of co-activator peptide after 2 hrs by TR-FRET assay				Bioorg Med Chem Lett 23: 4185-90 (2013)
Korea University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	103	n/a	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Binding affinity to human LXRbeta-LBD by surface plasmon resonance				Bioorg Med Chem Lett 23: 4185-90 (2013)
Korea University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Binding affinity to human LXRalpha-LBD by surface plasmon resonance				Bioorg Med Chem Lett 23: 4185-90 (2013)
Korea University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X Receptor alpha (LXR-alpha) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	4
Wyeth Research					Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...				J Med Chem 49: 6151-4 (2006)
Wyeth Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X Receptor beta (LXR-beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank MMDB PDB Article PubMed	n/a	n/a	10	n/a	16	n/a	n/a	7.4	4
Wyeth Research					Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...				J Med Chem 49: 6151-4 (2006)
Wyeth Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	7.5	22
GlaxoSmithKline					Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...				J Med Chem 48: 5419-22 (2005)
GlaxoSmithKline					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	7.5	22
GlaxoSmithKline					Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...				J Med Chem 48: 5419-22 (2005)
GlaxoSmithKline					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	7.5	22
GlaxoSmithKline					Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...				J Med Chem 45: 1963-6 (2002)
GlaxoSmithKline					More data for this Ligand-Target Pair				3D Structure (crystal)
Pregnane X receptor (PXR) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	Article PubMed	n/a	n/a	40	n/a	13	n/a	n/a	8.0	22
University of North Carolina at Chapel Hill					Assay Description Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....				Bioorg Med Chem 15: 2156-66 (2007)
University of North Carolina at Chapel Hill					More data for this Ligand-Target Pair
alpha-Glucosidase (alpha-Glu) (Saccharomyces cerevisiae)	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	7.0	37
University of Tokyo					Assay Description The alpha-glucosidase inhibitory activity of test compounds was determined in a 96-well plate format. The reaction mixture containing enzyme and chro...				Bioorg Med Chem 16: 4272-85 (2008)
University of Tokyo					More data for this Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Tanabe Research Laboratories USA					Assay Description Polyhistidine-tagged human LXR ligand-binding domain was mixed with the test compound, biotin-SRC1 peptide, streptavidin-allophycocyanin, and europiu...				Bioorg Med Chem Lett 17: 4442-6 (2007)
Tanabe Research Laboratories USA					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Tanabe Research Laboratories USA					Assay Description Polyhistidine-tagged human LXR ligand-binding domain was mixed with the test compound, biotin-SRC1 peptide, streptavidin-allophycocyanin, and europiu...				Bioorg Med Chem Lett 17: 4442-6 (2007)
Tanabe Research Laboratories USA					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X Receptor beta (LXR-beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank MMDB PDB Article PubMed	n/a	n/a	9	n/a	170	n/a	n/a	7.4	4
Wyeth Research					Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...				J Med Chem 51: 7161-8 (2008)
Wyeth Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X Receptor alpha (LXR-alpha) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	13	n/a	140	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...				J Med Chem 51: 7161-8 (2008)
Wyeth Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X Receptor alpha (LXR-alpha) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...				Bioorg Med Chem 17: 8086-92 (2009)
Wyeth Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X Receptor beta (LXR-beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank MMDB PDB Article PubMed	n/a	n/a	9	n/a	16	n/a	n/a	7.4	4
Wyeth Research					Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...				Bioorg Med Chem 17: 8086-92 (2009)
Wyeth Research					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Binding affinity to LXRbeta by radioligand displacement assay				Bioorg Med Chem Lett 16: 5231-7 (2006)
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Transactivation of LXRbeta by luciferase reporter gene assay				Bioorg Med Chem Lett 16: 5231-7 (2006)
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Transactivation of LXRalpha by luciferase reporter gene assay				Bioorg Med Chem Lett 16: 5231-7 (2006)
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domain				J Med Chem 51: 5758-65 (2008)
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
RAR-related orphan receptor C (RORc) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Antagonist activity at Gal4-fused RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assay				Eur J Med Chem 78: 431-41 (2014)
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
RAR-related orphan receptor C (RORc) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Antagonist activity at full-length RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assay				Eur J Med Chem 78: 431-41 (2014)
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
RAR-related orphan receptor C (RORc) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	2.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Antagonist activity at human His6-tagged RORgamma ligand binding domain (262 to 507 aa) assessed as inhibition of SRC1-4 co-activator peptide recruit...				Eur J Med Chem 78: 431-41 (2014)
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Nuclear receptor ROR-alpha (Homo sapiens)	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inverse agonist activity at human ROR-alpha1 expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay				Bioorg Med Chem 22: 2799-808 (2014)
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at human LXR-alpha expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay				Bioorg Med Chem 22: 2799-808 (2014)
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at human LXR-beta expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay				Bioorg Med Chem 22: 2799-808 (2014)
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
RAR-related orphan receptor C (RORc) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inverse agonist activity at human ROR-gamma1 expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay				Bioorg Med Chem 22: 2799-808 (2014)
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	135	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human LXRalpha expressed in Huh7 cells by Gal4 transactivation assay				Bioorg Med Chem Lett 18: 54-9 (2008)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity at human LXRbeta				Bioorg Med Chem Lett 18: 54-9 (2008)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	178	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta expressed in Huh7 cells by Gal4 transactivation assay				Bioorg Med Chem Lett 18: 54-9 (2008)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description Agonist activity at LXRbeta ligand binding domain (unknown origin) by FRET based SRC1 recruitment assay				Bioorg Med Chem Lett 19: 2009-12 (2009)
AstraZeneca R&D Södertälje Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 19: 2009-12 (2009)
AstraZeneca R&D Södertälje Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
AstraZeneca R&D Södertälje Curated by ChEMBL					Assay Description Agonist activity at LXRalpha ligand binding domain by FRET based SRC1 recruitment assay				Bioorg Med Chem Lett 19: 2009-12 (2009)
AstraZeneca R&D Södertälje Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRbeta ligand binding domain (154-461) expressed in Escherichia c...				Bioorg Med Chem 17: 3519-27 (2009)
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	178	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta ligand binding domain (219-462) expressed in human HuH7 cells cotransfected with Gal4-DBD by luciferase transactiva...				Bioorg Med Chem 17: 3519-27 (2009)
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRalpha ligand binding domain (197-447) expressed in Escherichia ...				Bioorg Med Chem 17: 3519-27 (2009)
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]T0901317 from human recombinant LXRbeta-LBD				Bioorg Med Chem Lett 20: 209-12 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method				Bioorg Med Chem Lett 20: 689-93 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	DrugBank PDB Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate method				Bioorg Med Chem Lett 20: 689-93 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta ligand binding domain expressed in human HuH7 cells co-transfected with Gal4-DBD by transactivation assay				Bioorg Med Chem Lett 20: 689-93 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]T0901317 from human recombinant LXRbeta LBD				Bioorg Med Chem Lett 20: 526-30 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human recombinant LXRbeta ligand binding domain in HuH7 cells by Gal4 transactivation assay				Bioorg Med Chem Lett 20: 2903-7 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]T0901317 from LXRbeta ligand binding domain				Bioorg Med Chem Lett 20: 2903-7 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human recombinant LXRalpha ligand binding domain in human HuH7 cells cotransfected with fused Gal4-DBD by transactivation assay				J Med Chem 53: 3296-304 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	53	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human LXRalpha in HEK293 cells assessed as Gal4 transactivation				J Med Chem 53: 3296-304 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human recombinant LXRbeta ligand binding domain in human HuH7 cells cotransfected with fused Gal4-DBD by transactivation assay				J Med Chem 53: 3296-304 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver X receptor (LXR alpha AND LXR beta) (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet	PDB Article PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta in HEK293 cells assessed as Gal4 transactivation				J Med Chem 53: 3296-304 (2010)
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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