BDBM19993 CHEMBL62136::N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide::T 0901317::T0901317::TO-901317::US10543183, Compound TO901317::US10669296, Compound TO901317::US10945978, Compound 1::[3H]T0901317
SMILES: OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
InChI Key: InChIKey=SGIWFELWJPNFDH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of radiolabeled T0901317 from LXRbeta LBD (unknown origin) | Bioorg Med Chem Lett 26: 5044-5050 (2016) Article DOI: 10.1016/j.bmcl.2016.08.089 BindingDB Entry DOI: 10.7270/Q28P62GC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of radiolabeled T0901317 from LXRalpha LBD (unknown origin) | Bioorg Med Chem Lett 26: 5044-5050 (2016) Article DOI: 10.1016/j.bmcl.2016.08.089 BindingDB Entry DOI: 10.7270/Q28P62GC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-Sen University Curated by ChEMBL | Assay Description Displacement of hyodeoxycholicacid-based fluorescent tracer from recombinant human LXRbeta LBD (215 to 461 residues) expressed in Escherichia coli BL... | Eur J Med Chem 194: (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Binding affinity to recombinant human LXRbeta-LBD expressed in Escherichia coli BL21 (DE3) assessed as inhibitory constant incubated for 30 mins by f... | Eur J Med Chem 178: 458-467 (2019) Article DOI: 10.1016/j.ejmech.2019.06.011 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to RORc (unknown origin) by radioligand binding assay | J Med Chem 57: 5871-92 (2014) Article DOI: 10.1021/jm401901d BindingDB Entry DOI: 10.7270/Q2M0473Z | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Nuclear receptor ROR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 132 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to RORa (unknown origin) by radioligand binding assay | J Med Chem 57: 5871-92 (2014) Article DOI: 10.1021/jm401901d BindingDB Entry DOI: 10.7270/Q2M0473Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 103 | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Agonist activity at human LXRbeta-LBD assessed as recruitment of co-activator peptide after 2 hrs by TR-FRET assay | Bioorg Med Chem Lett 23: 4185-90 (2013) Article DOI: 10.1016/j.bmcl.2013.05.030 BindingDB Entry DOI: 10.7270/Q2NK3GF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 91 | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Agonist activity at human LXRalpha-LBD assessed as recruitment of co-activator peptide after 2 hrs by TR-FRET assay | Bioorg Med Chem Lett 23: 4185-90 (2013) Article DOI: 10.1016/j.bmcl.2013.05.030 BindingDB Entry DOI: 10.7270/Q2NK3GF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 103 | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Binding affinity to human LXRbeta-LBD by surface plasmon resonance | Bioorg Med Chem Lett 23: 4185-90 (2013) Article DOI: 10.1016/j.bmcl.2013.05.030 BindingDB Entry DOI: 10.7270/Q2NK3GF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Binding affinity to human LXRalpha-LBD by surface plasmon resonance | Bioorg Med Chem Lett 23: 4185-90 (2013) Article DOI: 10.1016/j.bmcl.2013.05.030 BindingDB Entry DOI: 10.7270/Q2NK3GF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha [197-447] (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB MMDB Reactome pathway DrugBank GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Wyeth Research | Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test... | J Med Chem 49: 6151-4 (2006) Article DOI: 10.1021/jm0609566 BindingDB Entry DOI: 10.7270/Q20863KH | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Oxysterols receptor LXR-beta [154-461] (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB MMDB KEGG DrugBank GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 10 | n/a | 16 | n/a | n/a | 7.4 | 4 |
Wyeth Research | Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test... | J Med Chem 49: 6151-4 (2006) Article DOI: 10.1021/jm0609566 BindingDB Entry DOI: 10.7270/Q20863KH | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 55 | n/a | n/a | 7.5 | 22 |
GlaxoSmithKline | Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding... | J Med Chem 48: 5419-22 (2005) Article DOI: 10.1021/jm050532w BindingDB Entry DOI: 10.7270/Q26T0JXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 30 | n/a | n/a | 7.5 | 22 |
GlaxoSmithKline | Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding... | J Med Chem 48: 5419-22 (2005) Article DOI: 10.1021/jm050532w BindingDB Entry DOI: 10.7270/Q26T0JXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | 7.5 | 22 |
GlaxoSmithKline | Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding... | J Med Chem 45: 1963-6 (2002) Article DOI: 10.1021/jm0255116 BindingDB Entry DOI: 10.7270/Q2319T5G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 40 | n/a | 13 | n/a | n/a | 8.0 | 22 |
University of North Carolina at Chapel Hill | Assay Description Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA.... | Bioorg Med Chem 15: 2156-66 (2007) Article DOI: 10.1016/j.bmc.2006.12.026 BindingDB Entry DOI: 10.7270/Q2PG1Q15 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Alpha-glucosidase MAL32 (Saccharomyces cerevisiae) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | 7.0 | 37 |
University of Tokyo | Assay Description The alpha-glucosidase inhibitory activity of test compounds was determined in a 96-well plate format. The reaction mixture containing enzyme and chro... | Bioorg Med Chem 16: 4272-85 (2008) Article DOI: 10.1016/j.bmc.2008.02.078 BindingDB Entry DOI: 10.7270/Q28S4N7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc. | Assay Description Polyhistidine-tagged human LXR ligand-binding domain was mixed with the test compound, biotin-SRC1 peptide, streptavidin-allophycocyanin, and europiu... | Bioorg Med Chem Lett 17: 4442-6 (2007) Article DOI: 10.1016/j.bmcl.2007.06.017 BindingDB Entry DOI: 10.7270/Q2N58JQ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA, Inc. | Assay Description Polyhistidine-tagged human LXR ligand-binding domain was mixed with the test compound, biotin-SRC1 peptide, streptavidin-allophycocyanin, and europiu... | Bioorg Med Chem Lett 17: 4442-6 (2007) Article DOI: 10.1016/j.bmcl.2007.06.017 BindingDB Entry DOI: 10.7270/Q2N58JQ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta [154-461] (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB MMDB KEGG DrugBank GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 9 | n/a | 170 | n/a | n/a | 7.4 | 4 |
Wyeth Research | Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test... | J Med Chem 51: 7161-8 (2008) Article DOI: 10.1021/jm800799q BindingDB Entry DOI: 10.7270/Q2XW4H4G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Oxysterols receptor LXR-alpha [197-447] (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB MMDB Reactome pathway DrugBank GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 13 | n/a | 140 | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test... | J Med Chem 51: 7161-8 (2008) Article DOI: 10.1021/jm800799q BindingDB Entry DOI: 10.7270/Q2XW4H4G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Oxysterols receptor LXR-alpha [197-447] (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB MMDB Reactome pathway DrugBank GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of... | Bioorg Med Chem 17: 8086-92 (2009) Article DOI: 10.1016/j.bmc.2009.10.001 BindingDB Entry DOI: 10.7270/Q2VH5M54 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Oxysterols receptor LXR-beta [154-461] (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB MMDB KEGG DrugBank GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 9 | n/a | 16 | n/a | n/a | 7.4 | 4 |
Wyeth Research | Assay Description Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ... | Bioorg Med Chem 17: 8086-92 (2009) Article DOI: 10.1016/j.bmc.2009.10.001 BindingDB Entry DOI: 10.7270/Q2VH5M54 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc Curated by ChEMBL | Assay Description Binding affinity to LXRbeta by radioligand displacement assay | Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc Curated by ChEMBL | Assay Description Transactivation of LXRbeta by luciferase reporter gene assay | Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 250 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc Curated by ChEMBL | Assay Description Transactivation of LXRalpha by luciferase reporter gene assay | Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domain | J Med Chem 51: 5758-65 (2008) Article DOI: 10.1021/jm800612u BindingDB Entry DOI: 10.7270/Q28052FN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Antagonist activity at Gal4-fused RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assay | Eur J Med Chem 78: 431-41 (2014) Article DOI: 10.1016/j.ejmech.2014.03.065 BindingDB Entry DOI: 10.7270/Q2W66N9X | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Antagonist activity at full-length RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assay | Eur J Med Chem 78: 431-41 (2014) Article DOI: 10.1016/j.ejmech.2014.03.065 BindingDB Entry DOI: 10.7270/Q2W66N9X | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Antagonist activity at human His6-tagged RORgamma ligand binding domain (262 to 507 aa) assessed as inhibition of SRC1-4 co-activator peptide recruit... | Eur J Med Chem 78: 431-41 (2014) Article DOI: 10.1016/j.ejmech.2014.03.065 BindingDB Entry DOI: 10.7270/Q2W66N9X | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Nuclear receptor ROR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Inverse agonist activity at human ROR-alpha1 expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2799-808 (2014) Article DOI: 10.1016/j.bmc.2014.03.007 BindingDB Entry DOI: 10.7270/Q28K7BN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Agonist activity at human LXR-alpha expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2799-808 (2014) Article DOI: 10.1016/j.bmc.2014.03.007 BindingDB Entry DOI: 10.7270/Q28K7BN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Agonist activity at human LXR-beta expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2799-808 (2014) Article DOI: 10.1016/j.bmc.2014.03.007 BindingDB Entry DOI: 10.7270/Q28K7BN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Inverse agonist activity at human ROR-gamma1 expressed in HEK293 cells after 16 hrs by luciferase reporter gene assay | Bioorg Med Chem 22: 2799-808 (2014) Article DOI: 10.1016/j.bmc.2014.03.007 BindingDB Entry DOI: 10.7270/Q28K7BN8 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 135 | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human LXRalpha expressed in Huh7 cells by Gal4 transactivation assay | Bioorg Med Chem Lett 18: 54-9 (2008) Article DOI: 10.1016/j.bmcl.2007.11.013 BindingDB Entry DOI: 10.7270/Q2N879JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity at human LXRbeta | Bioorg Med Chem Lett 18: 54-9 (2008) Article DOI: 10.1016/j.bmcl.2007.11.013 BindingDB Entry DOI: 10.7270/Q2N879JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 178 | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human LXRbeta expressed in Huh7 cells by Gal4 transactivation assay | Bioorg Med Chem Lett 18: 54-9 (2008) Article DOI: 10.1016/j.bmcl.2007.11.013 BindingDB Entry DOI: 10.7270/Q2N879JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
AstraZeneca R&D Södertälje Curated by ChEMBL | Assay Description Agonist activity at LXRbeta ligand binding domain (unknown origin) by FRET based SRC1 recruitment assay | Bioorg Med Chem Lett 19: 2009-12 (2009) Article DOI: 10.1016/j.bmcl.2009.02.039 BindingDB Entry DOI: 10.7270/Q20C4VNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 75 | n/a | n/a | n/a | n/a |
AstraZeneca R&D Södertälje Curated by ChEMBL | Assay Description Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assay | Bioorg Med Chem Lett 19: 2009-12 (2009) Article DOI: 10.1016/j.bmcl.2009.02.039 BindingDB Entry DOI: 10.7270/Q20C4VNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
AstraZeneca R&D Södertälje Curated by ChEMBL | Assay Description Agonist activity at LXRalpha ligand binding domain by FRET based SRC1 recruitment assay | Bioorg Med Chem Lett 19: 2009-12 (2009) Article DOI: 10.1016/j.bmcl.2009.02.039 BindingDB Entry DOI: 10.7270/Q20C4VNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRbeta ligand binding domain (154-461) expressed in Escherichia c... | Bioorg Med Chem 17: 3519-27 (2009) Article DOI: 10.1016/j.bmc.2009.04.012 BindingDB Entry DOI: 10.7270/Q2T72HH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 178 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Agonist activity at human LXRbeta ligand binding domain (219-462) expressed in human HuH7 cells cotransfected with Gal4-DBD by luciferase transactiva... | Bioorg Med Chem 17: 3519-27 (2009) Article DOI: 10.1016/j.bmc.2009.04.012 BindingDB Entry DOI: 10.7270/Q2T72HH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRalpha ligand binding domain (197-447) expressed in Escherichia ... | Bioorg Med Chem 17: 3519-27 (2009) Article DOI: 10.1016/j.bmc.2009.04.012 BindingDB Entry DOI: 10.7270/Q2T72HH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of [3H]T0901317 from human recombinant LXRbeta-LBD | Bioorg Med Chem Lett 20: 209-12 (2010) Article DOI: 10.1016/j.bmcl.2009.10.132 BindingDB Entry DOI: 10.7270/Q2KW5G4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method | Bioorg Med Chem Lett 20: 689-93 (2010) Article DOI: 10.1016/j.bmcl.2009.11.062 BindingDB Entry DOI: 10.7270/Q2W66KV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate method | Bioorg Med Chem Lett 20: 689-93 (2010) Article DOI: 10.1016/j.bmcl.2009.11.062 BindingDB Entry DOI: 10.7270/Q2W66KV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human LXRbeta ligand binding domain expressed in human HuH7 cells co-transfected with Gal4-DBD by transactivation assay | Bioorg Med Chem Lett 20: 689-93 (2010) Article DOI: 10.1016/j.bmcl.2009.11.062 BindingDB Entry DOI: 10.7270/Q2W66KV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of [3H]T0901317 from human recombinant LXRbeta LBD | Bioorg Med Chem Lett 20: 526-30 (2010) Article DOI: 10.1016/j.bmcl.2009.11.099 BindingDB Entry DOI: 10.7270/Q2HT2PDZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human recombinant LXRbeta ligand binding domain in HuH7 cells by Gal4 transactivation assay | Bioorg Med Chem Lett 20: 2903-7 (2010) Article DOI: 10.1016/j.bmcl.2010.03.031 BindingDB Entry DOI: 10.7270/Q2TD9XJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM19993![]() (CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) | UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of [3H]T0901317 from LXRbeta ligand binding domain | Bioorg Med Chem Lett 20: 2903-7 (2010) Article DOI: 10.1016/j.bmcl.2010.03.031 BindingDB Entry DOI: 10.7270/Q2TD9XJZ | |||||||||||
More data for this Ligand-Target Pair |
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