BindingDB logo
myBDB logout

BDBM199947 US9226923, 5

SMILES: C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CC2(C1)CCCNC2)c1c(Cl)ccc(F)c1Cl

InChI Key: InChIKey=WUIOBNGTWSVFMF-MJPXCNCVNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 199947   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM199947
PNG
(US9226923, 5)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CC2(C1)CCCNC2)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1/C24H26Cl2FN5O/c1-14(21-18(25)3-4-19(27)22(21)26)33-20-7-15(10-30-23(20)28)16-11-31-32(12-16)17-8-24(9-17)5-2-6-29-13-24/h3-4,7,10-12,14,17,29H,2,5-6,8-9,13H2,1H3,(H2,28,30)/t14-,17?,24?/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 2.09n/an/an/an/an/an/a



Nanjing Allgen Pharma Co. Ltd.

US Patent


Assay Description
The inhibitory activities of compounds of Formula I were assay at Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pa., USA. Human ...


US Patent US9226923 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZT5
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM199947
PNG
(US9226923, 5)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CC2(C1)CCCNC2)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1/C24H26Cl2FN5O/c1-14(21-18(25)3-4-19(27)22(21)26)33-20-7-15(10-30-23(20)28)16-11-31-32(12-16)17-8-24(9-17)5-2-6-29-13-24/h3-4,7,10-12,14,17,29H,2,5-6,8-9,13H2,1H3,(H2,28,30)/t14-,17?,24?/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 1.92n/an/an/an/an/an/a



Nanjing Allgen Pharma Co. Ltd.

US Patent


Assay Description
The inhibitory activities of compounds of Formula I were assay at Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pa., USA. Human ...


US Patent US9226923 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZT5
More data for this
Ligand-Target Pair