BDBM200467 US10011599, Example 96::US9227969, 96::US9629836, 96

SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CC1)C(=O)CF)-c1ccc(Oc2ncccn2)cc1Cl

InChI Key InChIKey=MMAPEUSUQBHKFB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 200467   

LigandPNGBDBM200467(US9227969, 96 | US9629836, 96 | US10011599, Exampl...)
Affinity DataIC50: 40nMAssay Description:The radioactive filter binding assay is standardized using recombinant human activated BRAF (V599E) kinase (Cat No. 14-557) and kinase dead MEK1 (K97...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
US Patent

LigandPNGBDBM200467(US9227969, 96 | US9629836, 96 | US10011599, Exampl...)
Affinity DataIC50: 40nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent

LigandPNGBDBM200467(US9227969, 96 | US9629836, 96 | US10011599, Exampl...)
Affinity DataIC50: 40nMAssay Description:[MEK1 1mM ATP IC50 uM] A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent