BindingDB logo
myBDB logout

BDBM200609 US10011604, 35::US9227975, 35::US9796723, 35

SMILES: CC1CN(CC(C)N1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key: InChIKey=AUYIFEWYWPVPCL-NVQROZTENA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 200609   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200609
PNG
(US10011604, 35 | US9227975, 35 | US9796723, 35)
Show SMILES CC1CN(CC(C)N1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H27F2N7O/c1-14-12-30(13-15(2)27-14)23(33)28-22-11-26-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-16(24)5-6-18(17)25/h5-8,10-11,14-15,19,27H,3-4,9,12-13H2,1-2H3,(H,28,33)/t14?,15?,19-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 49.6n/an/an/an/a7.5n/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200609
PNG
(US10011604, 35 | US9227975, 35 | US9796723, 35)
Show SMILES CC1CN(CC(C)N1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H27F2N7O/c1-14-12-30(13-15(2)27-14)23(33)28-22-11-26-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-16(24)5-6-18(17)25/h5-8,10-11,14-15,19,27H,3-4,9,12-13H2,1-2H3,(H,28,33)/t14?,15?,19-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 49.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9796723 (2017)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q2CC12SB
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200609
PNG
(US10011604, 35 | US9227975, 35 | US9796723, 35)
Show SMILES CC1CN(CC(C)N1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H27F2N7O/c1-14-12-30(13-15(2)27-14)23(33)28-22-11-26-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-16(24)5-6-18(17)25/h5-8,10-11,14-15,19,27H,3-4,9,12-13H2,1-2H3,(H,28,33)/t14?,15?,19-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 49.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9795611 (2017)


Article DOI: 10.1021/jm061066t
BindingDB Entry DOI: 10.7270/Q25T3NMH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM200609
PNG
(US10011604, 35 | US9227975, 35 | US9796723, 35)
Show SMILES CC1CN(CC(C)N1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H27F2N7O/c1-14-12-30(13-15(2)27-14)23(33)28-22-11-26-20-7-8-21(29-32(20)22)31-9-3-4-19(31)17-10-16(24)5-6-18(17)25/h5-8,10-11,14-15,19,27H,3-4,9,12-13H2,1-2H3,(H,28,33)/t14?,15?,19-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 49.6n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...


US Patent US10011604 (2018)

More data for this
Ligand-Target Pair