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BDBM20061 5-Substituted-6-chlorouracil, 7a::6-chloro-5-(cyclopent-1-en-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

SMILES: Clc1[nH]c(=O)[nH]c(=O)c1C1=CCCC1

InChI Key: InChIKey=ZIEBNDBHRKPYIY-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20061   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thymidine Phosphorylase (TP)


(Homo sapiens (Human))
BDBM20061
PNG
(5-Substituted-6-chlorouracil, 7a | 6-chloro-5-(cyc...)
Show SMILES Clc1[nH]c(=O)[nH]c(=O)c1C1=CCCC1
Show InChI InChI=1S/C9H9ClN2O2/c10-7-6(5-3-1-2-4-5)8(13)12-9(14)11-7/h3H,1-2,4H2,(H2,11,12,13,14)
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
200 -9.50n/an/an/an/an/a6.437



Gilead Sciences Inc



Assay Description
The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...


J Med Chem 50: 6016-23 (2007)


Article DOI: 10.1021/jm070644i
BindingDB Entry DOI: 10.7270/Q2M043PX
More data for this
Ligand-Target Pair