BDBM202278 2-ethyl-3-methyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)methoxy)imidazo[1,2-b]pyridazine::Roche-Dataset for PDE10A, Compound 455::US9540384, 52
SMILES CCc1nc2ccc(OCc3cccc(n3)N3CCCC3)nn2c1C
InChI Key InChIKey=SYKXHAHUWFLUEW-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 202278
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche
F. Hoffmann-La Roche
Affinity DataIC50: 547nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche
F. Hoffmann-La Roche
Affinity DataIC50: 540nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair