BDBM20283 2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}acetamido)benzoic acid::NSC 74859::S3I-201::cid_252682

SMILES Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc1ccc(C(O)=O)c(O)c1

InChI Key InChIKey=HWNUSGNZBAISFM-UHFFFAOYSA-N

Data  1 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 20283   

TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 1-alpha/beta(Homo sapiens (Human))
University Of Central Florida College Of Medicine

LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50: >3.00E+5nMpH: 7.8 T: 2°CAssay Description:STAT proteins were expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 1-alpha/beta/3(Mus musculus (mouse))
University Of Central Florida College Of Medicine

LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  1.60E+5nMpH: 7.8 T: 2°CAssay Description:STAT proteins were expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  4.64E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibition of STAT3 (unknown origin) binding to DNA incubated for 30 mins by EMSA analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibition of STAT3 dimerization in EGF-stimulated mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  8.40E+4nMAssay Description:Binding affinity to Stat3 (unknown origin) using hSIE as probe preincubated for 30 mins followed by hSIE addition by electrophoretic mobility shift a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibition of STAT3 (unknown origin) dimerization by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibition of STAT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50:  8.60E+4nMpH: 7.8 T: 2°CAssay Description:STAT proteins were expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 1(Mus musculus)
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM20283(2-hydroxy-4-(2-{[(4-methylbenzene)sulfonyl]oxy}ace...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of STAT1 dimerization in EGF-stimulated mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT1-DNA interaction aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed