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BDBM203759 US9221809, 310

SMILES: CN([C@H](CO)c1ccccc1)c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1

InChI Key: InChIKey=OQMXFWLICHJWIP-NJPLCYPENA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 203759   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM203759
PNG
(US9221809, 310)
Show SMILES CN([C@H](CO)c1ccccc1)c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1
Show InChI InChI=1/C25H28N6O2S/c1-31(19(15-32)16-8-3-2-4-9-16)25-29-22(27-17-10-7-13-26-14-17)21(23(33)30-25)24-28-18-11-5-6-12-20(18)34-24/h2-6,8-9,11-12,17,19,26,32H,7,10,13-15H2,1H3,(H2,27,29,30,33)/t17-,19-/s2
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PC cid
PC sid
UniChem
US Patent
n/an/a 250n/an/an/an/a7.225



Merck Sharp & Dohme Corp

US Patent


Assay Description
A 20 ul reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (RP7030, Molecul...


US Patent US9221809 (2015)


BindingDB Entry DOI: 10.7270/Q23B5XZM
More data for this
Ligand-Target Pair