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BDBM203762 US9221809, 313

SMILES: O=c1[nH]c(nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1)N1CCC2CCCCC2C1

InChI Key: InChIKey=BSLVBLKTKZAEOS-FAFWIULHNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 203762   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM203762
PNG
(US9221809, 313)
Show SMILES O=c1[nH]c(nc(N[C@@H]2CCCNC2)c1-c1nc2ccccc2s1)N1CCC2CCCCC2C1
Show InChI InChI=1/C25H32N6OS/c32-23-21(24-28-19-9-3-4-10-20(19)33-24)22(27-18-8-5-12-26-14-18)29-25(30-23)31-13-11-16-6-1-2-7-17(16)15-31/h3-4,9-10,16-18,26H,1-2,5-8,11-15H2,(H2,27,29,30,32)/t16?,17?,18-/s2
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 330n/an/an/an/a7.225



Merck Sharp & Dohme Corp

US Patent


Assay Description
A 20 ul reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (RP7030, Molecul...


US Patent US9221809 (2015)


BindingDB Entry DOI: 10.7270/Q23B5XZM
More data for this
Ligand-Target Pair