BDBM20465 1-[(1R,2S)-6-fluoro-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl]-3-isoquinolin-5-ylurea::JNJ Compound

SMILES Fc1ccc2[C@@H](Cc3cccc(c3)C(F)(F)F)[C@H](CCc2c1)NC(=O)Nc1cccc2cnccc12

InChI Key InChIKey=XDTHHOJLKFLHNH-RSXGOPAZSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20465   

TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20465(1-[(1R,2S)-6-fluoro-1-{[3-(trifluoromethyl)phenyl]...)
Affinity DataKi:  58nM ΔG°:  -9.87kcal/mole EC50:  46nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed