BDBM20466 A-784168::CHEMBL482834::N-[4-(trifluoromethane)sulfonylphenyl]-1-[3-(trifluoromethyl)pyridin-2-yl]-1,2,3,6-tetrahydropyridine-4-carboxamide

SMILES FC(F)(F)c1cccnc1N1CCC(=CC1)C(=O)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F

InChI Key InChIKey=SDUAWRFBHRAFBM-UHFFFAOYSA-N

Data  1 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 20466   

TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20466(A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...)
Affinity DataKi:  71nM ΔG°:  -9.75kcal/mole EC50:  74nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM20466(A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at rat TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20466(A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...)
Affinity DataIC50:  1.40E+4nMpH: 5.5Assay Description:Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of pH 5.5-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20466(A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of capsaicin-induced calcium influx by FLIPR as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20466(A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...)
Affinity DataIC50:  2.02E+4nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in human 1321N1 cells assessed as inhibition of N-arachidonoyldopamine-induced calcium influ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed