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BDBM205017 US9550781, 14::n-(3-(3-(9h-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-3,4-difluorobenzenesulfonamide

SMILES: Fc1ccc(cc1F)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F

InChI Key: InChIKey=FSBHALPDNFWYRZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 205017   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
b-raf


()
BDBM205017
PNG
(US9550781, 14 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES Fc1ccc(cc1F)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C22H13F4N7O2S/c23-13-4-3-11(8-15(13)25)36(34,35)33-16-6-5-14(24)19(17(16)26)32-21-12(2-1-7-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31)
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<500n/an/an/an/an/an/a



Centaurus BioPharma Co., Ltd

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)


Article DOI: 10.1021/jm960093o
BindingDB Entry DOI: 10.7270/Q2X63PXK
More data for this
Ligand-Target Pair