BindingDB PrimarySearch

BDBM20608 4-Hydroxytamoxifen::4-Hydroxytamoxifen (9)::4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol::AFIMOXIFENE::CHEMBL489::[3H]4-OHT::cid_449459

SMILES: CC/C(=C(\c1ccc(cc1)O)/c2ccc(cc2)OCCN(C)C)/c3ccccc3

InChI Key: InChIKey=TXUZVZSFRXZGTL-UHFFFAOYSA-N

Data: 11 KI 37 IC50 6 EC50

PDB links: 14 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 53 hits for monomerid = 20608
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	9.90	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
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Aromatase (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
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Androgen receptor (Rat)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Aromatase (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen-related receptor gamma (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	21	n/a	32	n/a	n/a	n/a	25
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Progesterone receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.794	n/a	n/a	n/a	n/a	n/a	n/a
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Progesterone receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.309	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Rat)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
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Steroid hormone receptor ERR2 (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen-related receptor gamma (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	17	n/a	10.3	n/a	n/a	7.4	22
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	22
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Estrogen-related receptor gamma (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
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Estrogen-related receptor gamma (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	15	n/a	n/a	7.0	22
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Estrogen-related receptor gamma (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10.3	n/a	n/a	n/a	n/a	7.4	25
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Ubiquitin-conjugating enzyme E2 N (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phospholipase D1 (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Phospholipase D2 (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phospholipase D (Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22...)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	7.5	n/a
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Estrogen receptor (Mouse)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	0.0140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	0.390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM20608 ([3H]4-OHT \| cid_449459 \| CHEMBL489 \| AFIMOXIFENE \|...) Show SMILES Show InChI	GoogleScholar	UniChem	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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