Found 24 hits for monomerid = 20625 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar
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| PDB Article PubMed
| 0.126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Le Centre Hospitalier Universitaire de Qu£bec
Curated by ChEMBL
| Assay Description Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) |
J Med Chem 40: 2117-22 (1997)
Article DOI: 10.1021/jm970095o BindingDB Entry DOI: 10.7270/Q2474DKC |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
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| PDB Article PubMed
| 0.128 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Le Centre Hospitalier Universitaire de Qu£bec
Curated by ChEMBL
| Assay Description Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol |
J Med Chem 40: 2117-22 (1997)
Article DOI: 10.1021/jm970095o BindingDB Entry DOI: 10.7270/Q2474DKC |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| PDB Article PubMed
| 0.490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SignalGene Inc.
Curated by ChEMBL
| Assay Description In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alpha |
J Med Chem 46: 1408-18 (2003)
Article DOI: 10.1021/jm020536q BindingDB Entry DOI: 10.7270/Q20R9Q5J |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Estradiol receptor beta (ERβ)
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| Article PubMed
| 0.630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SignalGene Inc.
Curated by ChEMBL
| Assay Description In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor beta |
J Med Chem 46: 1408-18 (2003)
Article DOI: 10.1021/jm020536q BindingDB Entry DOI: 10.7270/Q20R9Q5J |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar
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| Article PubMed
| n/a | n/a | 8.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Balikesir University
| Assay Description CA activity was measured by the Maren method which is based on determination of the time required for the pH to decrease from 10.0 to 7.4 due to CO2 ... |
J Enzyme Inhib Med Chem 27: 208-10 (2012)
Article DOI: 10.3109/14756366.2011.584535 BindingDB Entry DOI: 10.7270/Q28051H4 |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| PDB Article PubMed
| n/a | n/a | n/a | n/a | 0.0100 | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description In vitro agonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells at 10 pM |
J Med Chem 44: 1654-7 (2001)
Article DOI: 10.1021/jm010086m BindingDB Entry DOI: 10.7270/Q2F47NDX |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
ATP-binding cassette sub-family G member 2
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar
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| PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Japanese Foundation for Cancer Research
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: drug resistance(Mitoxantrone) in BCRP-expressing K562 cells |
Mol Cancer Ther 2: 105-12 (2003)
BindingDB Entry DOI: 10.7270/Q2J104FD |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| PDB Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha |
J Med Chem 44: 1654-7 (2001)
Article DOI: 10.1021/jm010086m BindingDB Entry DOI: 10.7270/Q2F47NDX |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Estradiol receptor beta (ERβ)
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against [3H]-17-beta-estradiol binding to human estrogen receptor 2 |
J Med Chem 44: 1654-7 (2001)
Article DOI: 10.1021/jm010086m BindingDB Entry DOI: 10.7270/Q2F47NDX |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| PDB Article PubMed
| n/a | n/a | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Displacement of radioligand from Estrogen receptor alpha |
Bioorg Med Chem Lett 12: 1283-5 (2002)
Article DOI: 10.1016/s0960-894x(02)00144-0 BindingDB Entry DOI: 10.7270/Q2PG1R21 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Pregnane X receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Antagonist activity at full length human PXR transfected in human HepG2 cells assessed as reduction in rifaximin-induced receptor transactivation aft... |
Eur J Med Chem 103: 551-62 (2015)
Article DOI: 10.1016/j.ejmech.2015.09.005 BindingDB Entry DOI: 10.7270/Q2N87CMJ |
More data for this Ligand-Target Pair | |
Aldehyde oxidase
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Inhibition of human aldehyde oxidase |
J Med Chem 53: 8441-60 (2010)
Article DOI: 10.1021/jm100888d BindingDB Entry DOI: 10.7270/Q2057G6G |
More data for this Ligand-Target Pair | |
Estradiol receptor beta (ERβ)
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| Article PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
RWTH Aachen University
Curated by ChEMBL
| Assay Description Displacement of [3H]-estradiol from human recombinant ERbeta expressed in Sf21 cells after 2 hrs |
Bioorg Med Chem Lett 22: 4307-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.018 BindingDB Entry DOI: 10.7270/Q2416Z6R |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| PDB Article PubMed
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
RWTH Aachen University
Curated by ChEMBL
| Assay Description Displacement of [3H]-estradiol from human recombinant ERalpha expressed in Sf21 cells after 2 hrs |
Bioorg Med Chem Lett 22: 4307-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.018 BindingDB Entry DOI: 10.7270/Q2416Z6R |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
UDP-glucose 4-epimerase
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description Inhibition of human GalE by HPAEC assay |
Bioorg Med Chem Lett 16: 5744-7 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.091 BindingDB Entry DOI: 10.7270/Q2RJ4K83 |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family G member 2
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar
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| PubMed
| n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Japanese Foundation for Cancer Research
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: drug resistance(SN-38) in BCRP-expressing K562 cells |
Mol Cancer Ther 2: 105-12 (2003)
BindingDB Entry DOI: 10.7270/Q2J104FD |
More data for this Ligand-Target Pair | |
Androgen receptor
(Rattus norvegicus (Rat)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
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| Article PubMed
| n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Basel
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) |
J Med Chem 48: 5666-74 (2005)
Article DOI: 10.1021/jm050403f BindingDB Entry DOI: 10.7270/Q2TM7CBZ |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| PDB Article PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
the University of Tokyo
Curated by ChEMBL
| Assay Description Agonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ER-alpha-mediated transcriptional activit... |
Bioorg Med Chem 27: 1952-1961 (2019)
Article DOI: 10.1016/j.bmc.2019.03.042 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
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| PDB Article PubMed
| n/a | n/a | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a |
the University of Tokyo
Curated by ChEMBL
| Assay Description Selective estrogen receptor down-regulator activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ERalph... |
Bioorg Med Chem 27: 1952-1961 (2019)
Article DOI: 10.1016/j.bmc.2019.03.042 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| Article PubMed
| n/a | n/a | 9.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Balikesir University
| Assay Description CA activity was measured by the Maren method which is based on determination of the time required for the pH to decrease from 10.0 to 7.4 due to CO2 ... |
J Enzyme Inhib Med Chem 27: 208-10 (2012)
Article DOI: 10.3109/14756366.2011.584535 BindingDB Entry DOI: 10.7270/Q28051H4 |
More data for this Ligand-Target Pair | |
Estrogen-Related Receptor, gamma
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 630 | n/a | n/a | 7.0 | 22 |
GSK
| Assay Description Recruitment of the RIP140 NR-box peptide to the ERRgamma ligand binding domain was assayed by FRET detection. Proteins were set up in a one to one ra... |
J Med Chem 48: 3107-9 (2005)
Article DOI: 10.1021/jm050161j BindingDB Entry DOI: 10.7270/Q2S46Q77 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase
(Oryctolagus cuniculus) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
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Patents
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| Article PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chemistry and Technology Prague
Curated by ChEMBL
| Assay Description Inhibition of rabbit microsomes SERCA1a by enzyme-coupled method |
J Med Chem 63: 1937-1963 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01509 |
More data for this Ligand-Target Pair | |
Estrogen receptor
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
| Purchase
CHEBI CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 12 | n/a | 0.0600 | n/a | n/a | 7.4 | 22 |
Novartis Pharmaceuticals
| Assay Description Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA... |
J Med Chem 45: 1399-401 (2002)
Article DOI: 10.1021/jm015577l BindingDB Entry DOI: 10.7270/Q27M0665 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Estradiol receptor beta (ERβ)
(Homo sapiens (Human)) | BDBM20625
 (4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
| Purchase
CHEBI CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | 0.0200 | n/a | n/a | 7.4 | 22 |
Novartis Pharmaceuticals
| Assay Description Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA... |
J Med Chem 45: 1399-401 (2002)
Article DOI: 10.1021/jm015577l BindingDB Entry DOI: 10.7270/Q27M0665 |
More data for this Ligand-Target Pair | |