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BDBM207312 US9260439, 496

SMILES: C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@@]1(C)CCN(C1)C(=O)C1(F)CCN1

InChI Key: InChIKey=UHHXWKQCFNVTDC-PQJQJKMCNA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 207312   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207312
PNG
(US9260439, 496)
Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@@]1(C)CCN(C1)C(=O)C1(F)CCN1
Show InChI InChI=1/C24H32FN9O2/c1-15-13-36-10-9-33(15)22-30-18(16-11-27-21(26)28-12-16)17-3-7-34(19(17)31-22)23(2)5-8-32(14-23)20(35)24(25)4-6-29-24/h11-12,15,29H,3-10,13-14H2,1-2H3,(H2,26,27,28)/t15-,23-,24?/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<0.0180n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair