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BDBM208975 US9266881, 13-6

SMILES: O=c1n(C[C@@H]2C[C@H]2c2ccccn2)nc2cccc(N3CCOCC3)n12

InChI Key: InChIKey=NMRYGAKVQJYTDO-PVRQQBJHNA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 208975   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208975
PNG
(US9266881, 13-6)
Show SMILES O=c1n(C[C@@H]2C[C@H]2c2ccccn2)nc2cccc(N3CCOCC3)n12
Show InChI InChI=1/C19H21N5O2/c25-19-23(13-14-12-15(14)16-4-1-2-7-20-16)21-17-5-3-6-18(24(17)19)22-8-10-26-11-9-22/h1-7,14-15H,8-13H2/t14-,15+/s2
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
546 -8.54n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair