BDBM209325 US11136320, Reference Compound::US9266883, 83
SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N
InChI Key InChIKey=BHKDKKZMPODMIQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 209325
Affinity DataIC50: 1.90nMpH: 7.5 T: 2°CAssay Description:Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 9nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Southeast University
Curated by ChEMBL
Southeast University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human His-tagged FGFR4 (781 to 1338 residues) cytoplasmic domain expressed in baculovirus expression system using Tyr 04 pe...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Southeast University
Curated by ChEMBL
Southeast University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged FGFR1 (308 to 731 residues) cytoplasmic domain expressed in baculovirus expression system using Tyr 01 as ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged FGFR2 (403 to 822 residues) cytoplasmic domain expressed in baculovirus expression system using Tyr 04 pep...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged FGFR3 (399 to 806 residues) cytoplasmic domain expressed in baculovirus expression system using Tyr 04 pep...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:The FGFR4 kinase inhibition of compounds was tested by using mobility shift assay in this experiment, and the rate of FGFR4 kinase inhibition of comp...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of FGFR4 (unknown origin) expressed in HEK293 cells assessed as reduction in autophosphorylation by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Southeast University
Curated by ChEMBL
Southeast University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR2 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant His-tagged human FGFR4 expressed in baculovirus expression system using Tyr04 peptide as substrate preincubated in assay bu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human FGFR4 (447 to 753 residues) incubated for 30 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Southeast University
Curated by ChEMBL
Southeast University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR2 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin) expressed in Escherichia coli Rosetta2 (DE3) (NEB) cells in presence of ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Southeast University
Curated by ChEMBL
Southeast University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) using Tyr 04 peptide substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inhibition of FGFR4 (unknown origin) using Tyr 04 peptide substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR2 (unknown origin) using Tyr 04 peptide substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) using Tyr 04 peptide substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-L...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of FGFR4 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assayMore data for this Ligand-Target Pair