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BDBM20952 2-Aryloxy-4-alkoxy-pyridine, 33::4-{[3,6-dimethyl-4-(pentan-3-yloxy)pyridin-2-yl]oxy}-3,5-dimethylbenzamide

SMILES: CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(cc2C)C(N)=O)c1C

InChI Key: InChIKey=ZPSJLQMQKUVCKZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20952   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20952
PNG
(2-Aryloxy-4-alkoxy-pyridine, 33 | 4-{[3,6-dimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(cc2C)C(N)=O)c1C
Show InChI InChI=1S/C21H28N2O3/c1-7-17(8-2)25-18-11-14(5)23-21(15(18)6)26-19-12(3)9-16(20(22)24)10-13(19)4/h9-11,17H,7-8H2,1-6H3,(H2,22,24)
PDB
MMDB

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Similars

Article
PubMed
n/an/a 18n/an/an/an/a7.022



Pfizer Inc



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair