BDBM209864 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide::MLN-2480

SMILES C[C@H](c1ncc(s1)C(=O)Nc2cc(c(cn2)Cl)C(F)(F)F)NC(=O)c3c(c(ncn3)N)Cl

InChI Key InChIKey=VWMJHAFYPMOMGF-UHFFFAOYSA-N

Data  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 209864   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM209864(MLN-2480 | 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...)
Affinity DataIC50: 94nMAssay Description:Inhibition of wild type C-RAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM209864(MLN-2480 | 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...)
Affinity DataIC50: 94nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 2 [596-900](Human)
Technical University of Munich

LigandPNGBDBM209864(MLN-2480 | 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...)
Affinity DataKd:  484nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM209864(MLN-2480 | 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...)
Affinity DataIC50: 495nMAssay Description:Inhibition of RAF1 Y340D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM209864(MLN-2480 | 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...)
Affinity DataIC50: 633nMAssay Description:Inhibition of wild-type B-RAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)