BindingDB PrimarySearch

BDBM209864 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide::MLN-2480

SMILES: C[C@H](c1ncc(s1)C(=O)Nc2cc(c(cn2)Cl)C(F)(F)F)NC(=O)c3c(c(ncn3)N)Cl

InChI Key: InChIKey=VWMJHAFYPMOMGF-UHFFFAOYSA-N

Data: 1 Kd

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 209864
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ephrin type-A receptor 2 [596-900] (Human)	BDBM209864 (MLN-2480 \| 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	484	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM209864 (MLN-2480 \| 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM209864 (MLN-2480 \| 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	633	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM209864 (MLN-2480 \| 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM209864 (MLN-2480 \| 2-[(1R)-1-[(6-amino-5-chloropyrimidine-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	495	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair