BindingDB PrimarySearch

BDBM21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361

SMILES: CN1CCC(CC1)COc2cc3c(cc2OC)c(ncn3)Nc4ccc(cc4F)Br

InChI Key: InChIKey=UHTHHESEBZOYNR-UHFFFAOYSA-N

Data: 7 KI 96 IC50 914 Kd

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1017 hits for monomerid = 21
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vascular endothelial growth factor receptor 1 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	7.4	22
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Vascular endothelial growth factor receptor 2 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	25
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Fibroblast growth factor receptor 1 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	25
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Epidermal growth factor receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	25
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Vascular endothelial growth factor receptor 2 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	22	n/a	n/a	n/a	n/a	7.5	22
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Vascular endothelial growth factor receptor 1 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	78	n/a	n/a	n/a	7.4	25
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ALK tyrosine kinase receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	7.4	25
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Aurora kinase C (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase receptor UFO (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	11	n/a	n/a	n/a	7.4	25
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Discoidin domain-containing receptor 2 [A642S] (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	320	n/a	n/a	n/a	7.4	25
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Epidermal growth factor receptor [G719C] (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	9.60	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 3 [1-975] (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	50	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-B receptor 4 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	520	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	260	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	850	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	560	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	830	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 3 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	170	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase kinase kinase kinase 3 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Mer (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a
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MAP kinase-interacting serine/threonine-protein kinase 1 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a
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MAP kinase-interacting serine/threonine-protein kinase 2 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
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STE20-like serine/threonine-protein kinase (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 33 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a
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Citron Rho-interacting kinase (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM21 (VANDETANIB \| N-(4-bromo-2-fluorophenyl)-6-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
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