BDBM21130 N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide::N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl)benzeneacetamide::U-69593::U69,593::[3H]U69593

SMILES: CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N1CCCC1)C(=O)Cc1ccccc1

InChI Key: InChIKey=PGZRDDYTKFZSFR-UHFFFAOYSA-N

Data: 66 KI  8 IC50  10 Kd  41 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 127 hits for monomerid = 21130   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.20	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y66A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	18	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Q115A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y119A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	9.10	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y119F] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	8.10	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [I135A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	72	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [D138N] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	6.90E+3	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y139A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	28	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y139F] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.30	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [M142A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	19	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [K200A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [K212A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	17	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [M226A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.190	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [K227A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.20	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [H291A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	130	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [H291F] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.30	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [I294A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.70	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [E297A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.20	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y312A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	65	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y312F] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	5.60	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y313A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.20	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y313F] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.80	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [I316A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	19	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y320A] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	830	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor [Y320F] (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	150	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.60	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	205	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	131	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	5.40	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	248	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	84	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Guinea pig)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rat)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.630	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Guinea pig)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	684	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Guinea pig)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.89E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Guinea pig)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Guinea pig)	BDBM21130 (U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	684	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair