BDBM21395 3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione::3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}ethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione::CHEMBL1628637::CHEMBL51::Ketanserin::R-41,468::R-41-468::R41,468::US20240279226, Example Ketanserin::[3H]-Ketanserin

SMILES: c1ccc2c(c1)C(=O)N(C(=O)N2)CCN3CCC(CC3)C(=O)c4ccc(cc4)F

InChI Key: InChIKey=FPCCSQOGAWCVBH-UHFFFAOYSA-N

Data: 187 KI  32 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 222 hits for monomerid = 21395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 3 (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 2 (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 4 (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Synaptic vesicular amine transporter (Mouse)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Synaptic vesicular amine transporter (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1D (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1B (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Sigma non-opioid intracellular receptor 1 (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.660	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.660	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rat)	BDBM21395 (3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...) Show SMILES Show InChI	GoogleScholar	UniChem		0.850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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