BDBM21397 8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL267930::MLS000028615::SMR000058674::SPIPERONE::Spiroperidol::US9359372, Spiperone::[3H]-Spiroperidol::cid_5265

SMILES: c1ccc(cc1)N2CNC(=O)C23CCN(CC3)CCCC(=O)c4ccc(cc4)F

InChI Key: InChIKey=DKGZKTPJOSAWFA-UHFFFAOYSA-N

Data: 304 KI  21 IC50  3 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 327 hits for monomerid = 21397   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.0930	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1E (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	7.4	23
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Sphingosine 1-phosphate receptor 3 (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	37
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Bile salt export pump (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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HLA class I histocompatibility antigen, A alpha chain (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a
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D(3) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 7 (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
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D(4) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(4) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27	n/a	n/a	n/a	n/a	n/a	n/a
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Serotonin 2 (5-HT2) receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1B (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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5-hydroxytryptamine receptor 1A (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	123	n/a	n/a	n/a	n/a	n/a	n/a
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Sigma non-opioid intracellular receptor 1 (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	955	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 1/2/3 subunit alpha (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
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D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor (Mouse)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Mouse)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(2) dopamine receptor (Pig)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(4) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0530	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0580	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Rat)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0690	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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D(2) dopamine receptor (Human)	BDBM21397 (8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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