BDBM21436 N-Benylpiperazine derivative, 23d::N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]-4-(4-{[2-(methylsulfanyl)phenyl]methyl}piperazin-1-yl)benzamide

SMILES CSc1ccccc1CN1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN(C)C)CSc2ccccc2)c(c1)[N+]([O-])=O

InChI Key InChIKey=QSDXQZWJLWBNKS-SSEXGKCCSA-N

Data  2 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 21436   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21436(N-Benylpiperazine derivative, 23d | N-[(4-{[(2R)-4...)
Affinity DataKi: <0.5nM IC50: <60nM EC50:  95nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21436(N-Benylpiperazine derivative, 23d | N-[(4-{[(2R)-4...)
Affinity DataKi: <1nM EC50:  130nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM21436(N-Benylpiperazine derivative, 23d | N-[(4-{[(2R)-4...)
Affinity DataEC50:  95.1nMAssay Description:Inhibition of Bcl-XLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed