BDBM214799 1xx

InChI string: InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2

SMILES: FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl

InChI Key: InChIKey=BSPPZJZWKVYWNH-DUUNOXSYNA-N

Data: 26 KI  25 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 214799   

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
κ opioid receptor (KOR D138N) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR M142A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR D138A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR K227A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR H291F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR L212A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR E297A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR K200A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR M226A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR I135A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y139F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y312F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y139A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR H291A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y312A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y320F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR I294A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y313F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y119F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y66A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Q115A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	580	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR I316A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	890	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y313A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y320A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y119A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y119F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR I135A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR D138A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	36	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR D138N) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	9.10	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y139A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR M142A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR K200A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR L212A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR M226A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR K227A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR H291A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	890	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR H291F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR I294A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR E297A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	65	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y312A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	360	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y312F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y313A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y313F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	58	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR I316A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y119A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	590	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Q115A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y66A) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	51	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair
κ opioid receptor (KOR Y320F) (Homo sapiens (Human))	BDBM214799 (1xx) Show SMILES FC(F)(F)c1cc(NC(=O)[C@H]2CC=C[C@H]3CCN(Cc4ccccc4)C(=O)[C@@H]23)ccc1Cl Show InChI InChI=1/C24H22ClF3N2O2/c25-20-10-9-17(13-19(20)24(26,27)28)29-22(31)18-8-4-7-16-11-12-30(23(32)21(16)18)14-15-5-2-1-3-6-15/h1-7,9-10,13,16,18,21H,8,11-12,14H2,(H,29,31)/t16-,18-,21+/s2	PDB GoogleScholar AffyNet	PC cid PC sid UniChem AffyNet	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
University of North Carolina School of Medicine					Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described...				J Biol Chem 288: 34470-83 (2013)
					More data for this Ligand-Target Pair