BDBM21492 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline::CHEMBL261454::LY364947::US11759530, Compound Table1.1::US9138393, LY-364947::US9144538, LY-364947

SMILES: c1[nH]nc(c1-c1ccnc2ccccc12)-c1ccccn1

InChI Key: InChIKey=IBCXZJCWDGCXQT-UHFFFAOYSA-N

Data: 18 IC50  2 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 21492   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL2 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-2 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 20 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-1 [4-503,T204D] (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	40	n/a	n/a	7.5	30
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TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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TGF-beta receptor type-1 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase receptor R3 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM21492 (4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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