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BDBM215151 US9296736, 102::US9593129, Example 102

SMILES: C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H]2CC[C@@H](O)[C@H]2O)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key: InChIKey=CPDLQUCIPXCTHZ-QYYDPIRPNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 215151   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM215151
PNG
(US9296736, 102 | US9593129, Example 102)
Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H]2CC[C@@H](O)[C@H]2O)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1/C25H27Cl2NO5/c1-25(13-21(30)31)12-18(15-3-2-4-17(27)11-15)22(14-5-7-16(26)8-6-14)28(24(25)33)19-9-10-20(29)23(19)32/h2-8,11,18-20,22-23,29,32H,9-10,12-13H2,1H3,(H,30,31)/t18-,19+,20-,22-,23+,25-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 50n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9593129 (2017)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q20P1232
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (Human))
BDBM215151
PNG
(US9296736, 102 | US9593129, Example 102)
Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H]2CC[C@@H](O)[C@H]2O)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1/C25H27Cl2NO5/c1-25(13-21(30)31)12-18(15-3-2-4-17(27)11-15)22(14-5-7-16(26)8-6-14)28(24(25)33)19-9-10-20(29)23(19)32/h2-8,11,18-20,22-23,29,32H,9-10,12-13H2,1H3,(H,30,31)/t18-,19+,20-,22-,23+,25-/s2
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/a7.425



Amgen Inc

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair