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BDBM21586 2-(5-chloro-1'-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2,2',5'-trione)acetic acid::Spiro-indolinone analogue, 78

SMILES: OC(=O)CN1C(=O)C2(CC(=O)N(Cc3csc(n3)-c3ccc(Cl)cc3)C2=O)c2cc(Cl)ccc12

InChI Key: InChIKey=VJYXHXGNMCGAMT-UHFFFAOYNA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21586   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM21586
PNG
(2-(5-chloro-1'-{[2-(4-chlorophenyl)-1,3-thiazol-4-...)
Show SMILES OC(=O)CN1C(=O)C2(CC(=O)N(Cc3csc(n3)-c3ccc(Cl)cc3)C2=O)c2cc(Cl)ccc12
Show InChI InChI=1/C23H15Cl2N3O5S/c24-13-3-1-12(2-4-13)20-26-15(11-34-20)9-28-18(29)8-23(22(28)33)16-7-14(25)5-6-17(16)27(21(23)32)10-19(30)31/h1-7,11H,8-10H2,(H,30,31)
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Similars

Article
PubMed
55n/an/an/an/an/an/an/an/a



Merck Serono



Assay Description
A scintillation proximity assay was used for radioligand competition and saturation binding assays. Nonspecific binding was determined in the presenc...


J Med Chem 51: 2227-2243 (2008)


Article DOI: 10.1021/jm701383e
BindingDB Entry DOI: 10.7270/Q22R3PZS
More data for this
Ligand-Target Pair