BDBM21642 (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid::CHEMBL1560::Capozide::Captopril::Lopirin::SQ 14,225::SQ14534::US11491146, Compound L-Captopril
SMILES C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
InChI Key InChIKey=FAKRSMQSSFJEIM-RQJHMYQMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 92 hits for monomerid = 21642
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Inhibitory activity against rabbit lung angiotensin-1 converting enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Antihypertensive activity against human reninMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid after 60 mins by WST assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 2nMAssay Description:Specific activity of ACE was assayed in black 96-well microplates with or without various concentrations of inhibitors. N-Cbz-Phe-His-Leu was added, ...More data for this Ligand-Target Pair
Affinity DataKi: 48nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:To identify potential MBL inhibitors, the relative change in the formation of hydrolyzed nitrocefin between treated and untreated VIM2 was determined...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nM ΔG°: >-8.51kcal/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
TargetSuccinyl-diaminopimelate desuccinylase(Haemophilus influenzae)
Loyola University
Curated by ChEMBL
Loyola University
Curated by ChEMBL
Affinity DataKi: 1.82E+3nMAssay Description:Inhibition of Haemophilus influenzae recombinant DapE by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.70E+3nMAssay Description:Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-M...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:ECE activity was performed in black 96-well microplates with recombinant human ECE-1c (hECE-1c). The hECE-1c was preincubated with or without increa...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+4nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior ...More data for this Ligand-Target Pair
Affinity DataKi: 1.70E+4nMAssay Description:Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior ...More data for this Ligand-Target Pair
Affinity DataKi: 1.79E+4nMAssay Description:Inhibition of Bacillus anthracis MBL Bla2 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM IC50: >1.00E+5nMAssay Description:Inhibitory assay against ECE-2.More data for this Ligand-Target Pair
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of bacterial N-terminal His-tagged TEV protease site linked TEM-1 (24 to 286 amino acids) expressed in Escherichia coli Transetta (DE3) pr...More data for this Ligand-Target Pair
Affinity DataKi: 8.70E+6nMAssay Description:TP_TRANSPORTER: inhibition of D-Phe-L-Gln uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base. (reported from ref. 1b)More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Compound was tested for its inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:In vitro inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:In vitro inhibition of angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:In vitro 50% inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Ability to inhibit Angiotensin I converting enzyme was determinedMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme at pH 8.3More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme in rabbit lungMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human ACE-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of ACE (unknown origin) using 3-Hydroxybutylyl-Gly-Gly-Gly substrate assessed as reduction in 3-Hyroxybutylic acid generation incubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30E+5nMAssay Description:Inhibition of guinea pig lung leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human recombinant leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
Affinity DataKon: 0.0250M-1s-1Assay Description:Reversible binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 s...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) using nitrocefin as substrate prei...More data for this Ligand-Target Pair
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Uit The Arctic University Of Norway
Curated by ChEMBL
Uit The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.40E+4nMAssay Description:Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Uit The Arctic University Of Norway
Curated by ChEMBL
Uit The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 4.98E+4nMAssay Description:Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrateMore data for this Ligand-Target Pair
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Uit The Arctic University Of Norway
Curated by ChEMBL
Uit The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.41E+4nMAssay Description:Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Uit The Arctic University Of Norway
Curated by ChEMBL
Uit The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against recombinant human Leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against Leukotriene A4 hydrolase from human leukocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Compound was tested for inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:In vitro inhibition of rabbit lung Angiotensin I converting enzyme (ACE) using Hippuryl-His-Leu as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30E+5nMAssay Description:In vitro inhibition of rat kidney neutral endopeptidase (NEP) by fluorometric assay using Dansyl-Gly-Phe-Arg as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate.More data for this Ligand-Target Pair
Affinity DataIC50: 156nMAssay Description:In vitro antihypertensive activity determined by inhibition of angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of Angiotensin I converting enzyme in ratMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Squibb Institute For Medical Research
Curated by ChEMBL
Squibb Institute For Medical Research
Curated by ChEMBL
Affinity DataIC50: 0nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serumMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of guinea pig angiotensin I converting enzymeMore data for this Ligand-Target Pair