BDBM2168 (3-(2-tert-Butyl-5-methyl-phenylsulfanyl)-6-cyclopropyl-4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-5,6-dihydro-pyran-2-one::3-[(2-tert-butyl-5-methylphenyl)sulfanyl]-6-cyclopropyl-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-5,6-dihydro-2H-pyran-2-one::PD 178390 Analog 7

SMILES Cc1ccc(c(SC2C(=O)CC(CCc3ccc(O)cc3)(OC2=O)C2CC2)c1)C(C)(C)C

InChI Key InChIKey=BUEHASAXFVGSSK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 2168   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2168((3-(2-tert-Butyl-5-methyl-phenylsulfanyl)-6-cyclop...)
Affinity DataIC50:  8nMpH: 6.2 T: 2°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
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