BDBM218176 US9249087, 19

SMILES CN(C)CCc1cn(c2c1cccc2)Cc3ccc(cc3)C(=O)NO

InChI Key InChIKey=OQQDAERWKGMJMN-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 218176   

TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM218176(US9249087, 19)
Affinity DataIC50: 12.5nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM218176(US9249087, 19)
Affinity DataIC50: 20nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM218176(US9249087, 19)
Affinity DataIC50: 25nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM218176(US9249087, 19)
Affinity DataIC50: 126nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC6 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Illinois

US Patent
LigandPNGBDBM218176(US9249087, 19)
Affinity DataIC50: 422nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM218176(US9249087, 19)
Affinity DataIC50: 5.86E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent