BDBM21958 2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole Hydrochloride::US10660877, Example 1

SMILES: Cc1cc(cc(n1)C)c2c(c3cc(ccc3[nH]2)C4CCNCC4)C(C)C

InChI Key: InChIKey=XSXCQWXAFRASGU-UHFFFAOYSA-N

Data: 15 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 21958   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 8 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 9 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	302	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 7 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 8 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 9 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 3 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 4 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 9 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 7 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Toll-like receptor 9 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 8 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Human)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 9 (Mouse)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Mouse)	BDBM21958 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair