BDBM220368 US9290488, C20a(ii)
SMILES CC12C[C@@H]3C[C@H]1C[C@H]2C[C@@H](C3)N1[C@H]2COC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC[C@H]2C(O)=O)c1=O
InChI Key InChIKey=WNIKNGMOHBBZMW-ZXDPNDLZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 220368
Affinity DataKi: 55.5nM ΔG°: -9.89kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
Affinity DataKi: 2.83E+3nM ΔG°: -7.56kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-receptors (Perkin Elmer, Shelton, Conn.). Radioligand ...More data for this Ligand-Target Pair
Affinity DataKi: 7.05E+3nM ΔG°: -7.02kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
Affinity DataKi: 7.67E+3nM ΔG°: -6.97kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 μg membrane protein (recombinant delta opioid re...More data for this Ligand-Target Pair
Affinity DataEC50: 146nMpH: 7.4 T: 2°CAssay Description:ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...More data for this Ligand-Target Pair