BDBM221688 US10568884, Cpd 9::US12076320, Example L-5-S::US9314464, 9::US9593100, Compound 9::USRE49556, Compound 9

SMILES: COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C(C)C

InChI Key: InChIKey=CMJCXYNUCSMDBY-UHFFFAOYSA-N

Data: 26 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 221688   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.43	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.41	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.58	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.66	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.26	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.57	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.64	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.49	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.98	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.49	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.95	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM221688 (US9314464, 9 | US9593100, Compound 9 | US10568884,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair