BDBM2217 2-Pyridinone derivative 12::3-[2-(1-benzofuran-2-yl)ethyl]-5-ethyl-6-methyl-1,2-dihydropyridin-2-one::CHEMBL98159::Pyridinone deriv. 9

SMILES CCc1cc(CCc2cc3ccccc3o2)c(=O)[nH]c1C

InChI Key InChIKey=SJASAUDWUFJISL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2217   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM2217(2-Pyridinone derivative 12 | 3-[2-(1-benzofuran-2-...)
Affinity DataIC50:  77nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Merck Reserch Laboratories

Curated by ChEMBL
LigandPNGBDBM2217(2-Pyridinone derivative 12 | 3-[2-(1-benzofuran-2-...)
Affinity DataIC50:  130nMAssay Description:Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM2217(2-Pyridinone derivative 12 | 3-[2-(1-benzofuran-2-...)
Affinity DataIC50:  130nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed