BDBM22176 (2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazin-1-yl)-3-phenylpropan-2-amine::GBR 12935 Analogue, (S)-8

SMILES N[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1

InChI Key InChIKey=RYTXLXDKGBGSQO-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22176   

TargetSodium-dependent dopamine transporter(Rat)
National Taiwan University

LigandPNGBDBM22176((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Affinity DataKi:  39nM ΔG°:  -9.39kcal/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Taiwan University

LigandPNGBDBM22176((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Affinity DataKi:  88nMAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed