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BDBM222112 (E)-4-(3,4-Dichlorophenyl)-2-(2-(pyren-1-ylmethylene)hydrazinyl)thiazole (11)

SMILES: Clc1ccc(cc1Cl)-c1csc(N\N=C\c2ccc3ccc4cccc5ccc2c3c45)n1

InChI Key: InChIKey=QUHVGGYNGUVXJC-VFLNYLIXSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222112   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))
BDBM222112
PNG
((E)-4-(3,4-Dichlorophenyl)-2-(2-(pyren-1-ylmethyle...)
Show SMILES Clc1ccc(cc1Cl)-c1csc(N\N=C\c2ccc3ccc4cccc5ccc2c3c45)n1
Show InChI InChI=1S/C26H15Cl2N3S/c27-21-11-9-18(12-22(21)28)23-14-32-26(30-23)31-29-13-19-7-6-17-5-4-15-2-1-3-16-8-10-20(19)25(17)24(15)16/h1-14H,(H,30,31)/b29-13+
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KEGG

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.20E+3n/an/an/an/an/an/a



University of Karachi



Assay Description
β-Glucuronidase inhibitory activity was measured by quantifying the absorbance of para-nitrophenol which was formed from the substrate by the sp...


Bioorg Chem 70: 199-209 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.011
BindingDB Entry DOI: 10.7270/Q2VH5MQ9
More data for this
Ligand-Target Pair