BDBM223086 Isobutyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)-piperazine-1-carboxylate (3f)

SMILES CC(C)COC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1

InChI Key InChIKey=IFVGNYDOUDEVPK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 223086   

TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences

LigandPNGBDBM223086(Isobutyl 4-(6-((5-((2-chloro-6-methylphenyl)carbam...)
Affinity DataIC50:  6.75nMpH: 7.5 T: 2°CAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences

LigandPNGBDBM223086(Isobutyl 4-(6-((5-((2-chloro-6-methylphenyl)carbam...)
Affinity DataIC50:  0.440nMpH: 7.5 T: 2°CAssay Description:ABL activity assays were performed in 384-well plate using the FRET-based Z'-Lyteassay system and Tyr-2 peptide substrate according to the manufa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences

LigandPNGBDBM223086(Isobutyl 4-(6-((5-((2-chloro-6-methylphenyl)carbam...)
Affinity DataIC50:  34.6nMpH: 7.5 T: 2°CAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed