BDBM223751 US9540377, 12.13::methyl 6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl)methyl]- 8-[(3r)-3- phenylmorpholin-4-yl]- 7h-purine-2-carboxylate

SMILES COC(=O)c1nc(N[C@H](C)C2CCC2)c2n(C[C@H]3CC[C@H](C)CC3)c(nc2n1)N1CCOC[C@H]1c1ccccc1

InChI Key InChIKey=ANFUAKMPMGMGNB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223751   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM223751(US9540377, 12.13 | methyl 6-{[(1r)-1- cyclobutylet...)
Affinity DataIC50: 49.4nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent