BDBM223984 rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine (1)

SMILES COc1ccccc1CN1C[C@@H]([C@H](C1)c1cn(C)c2ccccc12)N(C)C

InChI Key InChIKey=CXQQECCQTKSQKN-IRLDBZIGSA-N

Data  4 KI  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 223984   

TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKi:  600nMAssay Description:Binding affinity to GST tagged EED (unknown origin) after 1 hr by OG(488) probe based TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKi:  600nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKi:  600nMAssay Description:Inhibition of OG(488) labeled probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKi:  1.20E+3nM ΔG°:  -8.07kcal/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKd:  3.80E+4nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB