BDBM22416 (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::CHEMBL490::PAROXETINE::US09969700, Paroxetine::US9944618, Compound ID No. 182::[3H]Paroxetine

SMILES: c1cc(ccc1[C@@H]2CCNC[C@H]2COc3ccc4c(c3)OCO4)F

InChI Key: InChIKey=AHOUBRCZNHFOSL-UHFFFAOYSA-N

Data: 101 KI  37 IC50  7 Kd

PDB links: 10 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 145 hits for monomerid = 22416   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Envelope glycoprotein (ZEBOV)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.50E+5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rhodopsin kinase GRK1 (Bovine)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G protein-coupled receptor kinase 5 (Bovine)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-adrenergic receptor kinase 1 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-adrenergic receptor kinase 1 (Bovine)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.43	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-adrenergic receptor kinase 1 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.98E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-adrenergic receptor kinase 1 (Bovine)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-adrenergic receptor kinase 1 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-adrenergic receptor kinase 1 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rhodopsin kinase GRK1 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G protein-coupled receptor kinase 5 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Quinolone resistance protein NorA (Staphylococcus aureus)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	623	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transporter (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	535	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Substance-P receptor (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G protein-coupled receptor kinase 5 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rhodopsin kinase GRK1 (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Myeloperoxidase (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM22416 (PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair