BDBM224230 3-{8-[(2s,5s)-2,5- bis(methoxymethyl) pyrrolidin-1-yl]-6-(3- chlorophenyl)-7- [(trans-4- methylcyclohexyl) methyl]-7h-purin-2-yl}- 1,2,4-oxadiazol- 5(4h)-one::US9540377, 16.149

SMILES COC[C@@H]1CC[C@@H](COC)N1c1nc2nc(nc(-c3cccc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224230   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224230(3-{8-[(2s,5s)-2,5- bis(methoxymethyl) pyrrolidin-1...)
Affinity DataIC50:  3.77nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent