BDBM224276 6-(((r)-1-cyclobutylethyl)amino)-7- ((trans-4-ethylcyclohexyl)methyl)-8- (4-isopropylpyridin-2-yl)-7h-purine- 2-carboxylic acid::US9540377, 18.17::US9540377, 18.2

SMILES CC[C@H]1CC[C@H](Cn2c(nc3nc(nc(N[C@H](C)C4CCC4)c23)C(O)=O)-c2cc(ccn2)C(C)C)CC1

InChI Key InChIKey=WLLLONIWVLNEEB-VAMGGRTRSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224276   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224276(6-(((r)-1-cyclobutylethyl)amino)-7- ((trans-4-ethy...)
Affinity DataIC50:  8.16nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224276(6-(((r)-1-cyclobutylethyl)amino)-7- ((trans-4-ethy...)
Affinity DataIC50:  2.49nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent