BDBM22435 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hydroxy-2-phenylpent-1-en-1-yl]phenol::4-hydroxytamoxifen (4-OHT) analog, 15::GSK 5182::US10934303, Example GSK5182::US11285226, Compound GSK5182

SMILES: CN(C)CCOc1ccc(cc1)/C(=C(/CCCO)\c2ccccc2)/c3ccc(cc3)O

InChI Key: InChIKey=ZVSFNBNLNLXEFQ-UHFFFAOYSA-N

Data: 41 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 22435   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR1 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen receptor (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR1 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen receptor (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR1 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen receptor (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	79	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR1 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen receptor (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR1 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen receptor (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen receptor (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen receptor (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	320	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR1 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Estrogen receptor (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR1 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM22435 (4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair