BDBM224445 US10080750, Compound 122::US9321760, 122::US9662330, Compound 122

SMILES Nc1ncnc(N2CCN(CC2)C(CN2CCC2)c2ccc3CCCCc3c2)c1-c1cn[nH]c1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224445   

TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM224445(US10080750, Compound 122 | US9321760, 122 | US9662...)
Affinity DataIC50:  950nMpH: 7.5Assay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM224445(US10080750, Compound 122 | US9321760, 122 | US9662...)
Affinity DataIC50:  950nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1 [T412E](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM224445(US10080750, Compound 122 | US9321760, 122 | US9662...)
Affinity DataIC50:  950nMpH: 7.5Assay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent