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BDBM224894 US9321756, 147

SMILES: Cc1[nH]c2ccc(CNc3nnc(s3)-c3ccc4[nH]cc(-c5ccc(F)cc5F)c4c3)cc2c1C

InChI Key: InChIKey=ZLHYWOFEGYHJPI-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224894   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224894
PNG
(US9321756, 147)
Show SMILES Cc1[nH]c2ccc(CNc3nnc(s3)-c3ccc4[nH]cc(-c5ccc(F)cc5F)c4c3)cc2c1C
Show InChI InChI=1S/C27H21F2N5S/c1-14-15(2)32-25-7-3-16(9-20(14)25)12-31-27-34-33-26(35-27)17-4-8-24-21(10-17)22(13-30-24)19-6-5-18(28)11-23(19)29/h3-11,13,30,32H,12H2,1-2H3,(H,31,34)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 634n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM224894
PNG
(US9321756, 147)
Show SMILES Cc1[nH]c2ccc(CNc3nnc(s3)-c3ccc4[nH]cc(-c5ccc(F)cc5F)c4c3)cc2c1C
Show InChI InChI=1S/C27H21F2N5S/c1-14-15(2)32-25-7-3-16(9-20(14)25)12-31-27-34-33-26(35-27)17-4-8-24-21(10-17)22(13-30-24)19-6-5-18(28)11-23(19)29/h3-11,13,30,32H,12H2,1-2H3,(H,31,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM224894
PNG
(US9321756, 147)
Show SMILES Cc1[nH]c2ccc(CNc3nnc(s3)-c3ccc4[nH]cc(-c5ccc(F)cc5F)c4c3)cc2c1C
Show InChI InChI=1S/C27H21F2N5S/c1-14-15(2)32-25-7-3-16(9-20(14)25)12-31-27-34-33-26(35-27)17-4-8-24-21(10-17)22(13-30-24)19-6-5-18(28)11-23(19)29/h3-11,13,30,32H,12H2,1-2H3,(H,31,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 513n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair